Experience in Inhalation Studies

 

Study Types   

  • All study durations from acute to 104 week carcinogenicity including toxicokinetic and also biopersistence studies.

  • Reproductive toxicity (Segment I to III) and Irwin Screen studies as deputy study director.

Species   

  • Mouse (including the strains Tg-rasH2 and SCID
    [Severe Combined Immuno-Deficiency])

  • Rat

  • Rabbit

  • Dog

Test Materials

(Powder, liquid, suspension, MDI, vapour, gas)    

  • Pharmaceuticals: Broncho dilators, corticosteroids, heparin, neuramidase inhibitor, prostacyclin analogue, S-nitroso-glutathione, various peptides (e.g. alpha proteinase inhibitor, chloride channel activator, endothelial sodium channel peptide, fibroblast growth factor)

  • Chemicals: Carbon nanotubes, fibers, hydrofluorocarbons, siloxanes, silylamines, toner, vanadium pentoxide, various other chemicals (powder, liquids, vapours, gases)

  • Agrochemicals: Various pesticides (powder, liquids, suspensions)

  • Experience with instable, hygroscopic, explosive or self-igniting properties

Special endpoints    

  • Plasma and lung levels and toxicokinetics

  • Immunotoxicity and primary immune response

  • Cell differentiation and biochemistry in broncho-alveolar lavage fluid (BALF)

  • Respiratory function

  • Electrocardiograms

  • Genotoxicity: Lung cell proliferation, comet assay, DNA adducts, micronuclei


Several studies were published in peer reviewed journals or presented as lectures or posters.

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